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How Quickly Does Hylenex Work?

Dermal fillers are a popular way to add volume, smooth wrinkles, and enhance facial features without surgery. But what happens if you don’t love your filler results? Or what if your filler moves, looks uneven, or forms lumps?

The good news is that the filler is not permanent. And if you don’t want to wait for it to break down naturally, there is a safe and effective solution that works much faster: Hylenex.

At Glow Aesthetic Center in Encino, CA, we offer Hylenex treatments for patients who want to dissolve their filler quickly and safely. In this blog, we’ll explain exactly what Hylenex is, how it works, and, most importantly, how quickly you can expect to see results.

What is Hylenex?

Hylenex is a special injectable medication that dissolves hyaluronic acid (HA) fillers. Most popular fillers like Juvederm, Restylane, and other lip or facial fillers are made with HA. Hylenex breaks down that HA so your body can absorb it naturally.

Hylenex is the brand name for a type of enzyme called hyaluronidase. This enzyme occurs naturally in the body and breaks down hyaluronic acid. When injected into an area with filler, Hylenex works quickly, dissolving the filler and helping your body clear it away.

Why Do People Use Hylenex?

Most patients love their filler results. But sometimes things don’t go as planned. There are several reasons why someone might want to dissolve their filler with Hylenex:

  • The filler looks uneven or lumpy
  • The filler has migrated (moved to a different area)
  • The area looks overfilled or unnatural
  • There is swelling that won’t go away
  • The patient simply changed their mind
  • Rare reactions or complications like vascular occlusion (blockage of a blood vessel)

Whatever the reason, Hylenex is a safe and effective option to correct or remove unwanted filler.

How Does Hylenex Work?

Once Hylenex is injected into the area where filler was placed, it immediately starts breaking down the hyaluronic acid particles in the filler. The enzyme breaks the bonds that hold the filler together, turning it into smaller pieces that the body can absorb.

Your body then naturally clears away the dissolved filler through its lymphatic system over the next few days.

How Quickly Does Hylenex Start Working?

One of Hylenex’s biggest benefits is how quickly it starts working. In fact, Hylenex has a half-life of just 2 to 3 minutes. This means it gets to work almost immediately after injection. Most patients see early changes within the first few minutes after treatment. You may notice that areas that look overfilled or lumpy start to look softer very quickly.

However, the full process of dissolving filler doesn’t happen all at once. While Hylenex gets to work right away, your body still needs time to break down and remove the dissolved filler completely.

What Results Can I Expect in the First 24-48 Hours?

You should see significant improvement in the treated area within 24 to 48 hours after your Hylenex treatment. Most of the filler will have broken down by this time, and you should notice:

  1. A softer, more natural look
  2. Reduced lumps or unevenness
  3. Less puffiness or swelling
  4. A return to your original facial contours

It’s important to know that some swelling from the injection is common. This is normal and usually goes away within a few days. So even though the filler may be gone, you might not see the final result until any injection swelling has settled.

What About Results After 48 Hours?

By 48 hours after treatment, most—if not all—of the unwanted filler should be dissolved. At this point, any swelling caused by the Hylenex injection will usually start to go down.

For some patients, it can take up to 3 to 5 days for all swelling to fully resolve, especially if a large amount of filler was dissolved or the area was already sensitive.

You should have a clear idea of your final results by the end of the first week after treatment.

Will I Need More Than One Hylenex Treatment?

In many cases, one Hylenex treatment is enough to dissolve the unwanted filler completely. However, this depends on several factors, including:

  1. How much filler was placed
  2. How long the filler has been in the area
  3. The type of filler used (some fillers are thicker or more resistant)
  4. Your body’s response to the enzyme

If any filler remains after your first Hylenex treatment, your practitioner at Glow Aesthetic Center may recommend a follow-up treatment after a few days.

Does Hylenex Work Instantly?

Hylenex begins to work instantly once injected. But it’s important to understand that “instantly” doesn’t mean your filler disappears when Hylenex touches it.

Think of Hylenex like a cleaning solution. It starts breaking down the filler right away, but your body still needs time to sweep away the dissolved particles. That process takes about 24 to 48 hours for most patients.

What Can I Expect After My Hylenex Treatment at Glow Aesthetic Center?

Here’s a simple breakdown of what you can expect after your Hylenex filler-dissolving treatment at Glow Aesthetic Center:

Right After Treatment (First Hour)

  • Mild stinging or tenderness at the injection site
  • Some swelling or redness
  • Possible early softening of the filler

24-48 Hours After Treatment

  • Most of the filler dissolved
  • Swelling starting to go down
  • Noticeable improvement in treated area

3-5 Days After Treatment

  • Swelling mostly gone
  • Final results becoming clear

1 Week After Treatment

  • Full results visible
  • Treated area returned to pre-filler appearance

Will My Face Look Exactly Like It Did Before Filler?

In most cases, yes. Hylenex breaks down the filler and leaves your natural tissue untouched. Once the swelling goes down and your body clears away the dissolved filler, your treated area should look similar to how it did before filler was placed.

However, keep in mind that fillers sometimes mask natural features like fine lines, volume loss, or asymmetry. Once the filler is gone, those features may become visible again.

Learn More About Hylenex

At Glow Aesthetic Center in Encino, CA, we understand that cosmetic treatments are personal and sometimes you simply want to hit the reset button.

Contact Glow Aesthetic Center today to schedule your consultation and learn how Hylenex can work quickly to restore your natural look.

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Glow Aesthetic Center is celebrating May with incredible savings on popular treatments like Sculptra & Radiesse non-invasive butt lifts, and PRP hair growth. Whether you’re a member or not, now’s the perfect time to refresh your look at our Encino or Thousand Oaks locations.

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Encino, Los Angeles
Working hours:

Sunday: 9 AM–4:30 PM
Monday:
9 AM–4 PM
Tuesday: 9 AM–6 PM
Wednesday: 9 AM–4 PM
Thursday: 9 AM–6 PM
Friday: 9 AM–4 PM
Saturday: Closed

Thousand Oaks, Ventura
Working hours:

Sunday: 9 AM–4:30 PM
Monday:
9 AM–4 PM
Tuesday: 9 AM–6 PM
Wednesday: 9 AM–4 PM
Thursday: 9 AM–6 PM
Friday: 9 AM–4 PM
Saturday: Closed

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